REVIEW ARTICLE

The role of endothelial glycocalyx in sepsis

I Nyoman Budi Hartawan , Made Wiryana

I Nyoman Budi Hartawan
Department of Anesthesiology, Pain Management, and Intensive Care Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia. Email: mangdut@gmail.com

Made Wiryana
Department of Anesthesiology, Pain Management, and Intensive Care Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia
Online First: April 28, 2019 | Cite this Article
Hartawan, I., Wiryana, M. 2019. The role of endothelial glycocalyx in sepsis. Bali Journal of Anesthesiology 3(1): 27-32. DOI:10.15562/bjoa.v3i1.114


ABSTRACT

The surface of endothelial cells is filled with various membrane-bound molecules that form the glycocalyx. The endothelial glycocalyx is a surface layer mainly consisted of glycosaminoglycans that include heparan sulfate, chondroitin sulfate, and hyaluronic acid and its core proteins. Previous studies suggest that endothelial surface glycocalyx shedding could play a role in endothelial dysfunction and inflammation. This article will review the endothelial glycocalyx and its role in sepsis. 

References

REFERENCES

Gouverneur M, Van Den Berg B, Nieuwdorp M, et al. Vasculoprotective properties of the endothelial glycocalyx: Effects of fluid shear stress. Journal of Internal Medicine. 2006; 259(4): 393-400. DOI: 10.1111/j.1365-2796.2006.01625.x

Reitsma S, Slaaf DW, Vink H, et al. The endothelial glycocalyx: Composition, functions, and visualization. Pflugers Arch Eur J Physiol. 2007; 454(3): 345-59. DOI: 10.1007/s00424-007-0212-8

Becker BF, Chappell D, Jacob M. Endothelial glycocalyx and coronary vascular permeability: The fringe benefit. Basic Res Cardiol. 2010; 105(6): 687-701. DOI: 10.1007/s00395-010-0118-z

Woodcock TE, Woodcock TM. Revised Starling equation and the glycocalyx model of transvascular fluid exchange: An improved paradigm for prescribing intravenous fluid therapy. Br J Anaesth. 2012; 108(3): 384-94. DOI: 10.1093/bja/aer515

Alphonsus CS, Rodseth RN. The endothelial glycocalyx: A review of the vascular barrier. Anesthesia. 2014; 69(7): 777-84. DOI: 10.1111/anae.12661

Kolářová H, Ambrůzová B, Švihálková Šindlerová L, et al. Modulation of endothelial glycocalyx structure under inflammatory conditions. Mediators Inflamm. 2014; 2014: 694312. DOI:10.1155/2014/694312

Zeng Y. Endothelial glycocalyx as a critical signaling platform integrating the extracellular hemodynamic forces and chemical signaling. J Cell Mol Med. 2017; 21(8): 1457-62. DOI: 10.1111/jcmm.13081

Mulivor AW. Inflammation and ischemia-induced shedding of venular glycocalyx. AJP Heart Circ Physiol. 2004; 286(5): H1672-80. DOI: 10.1152/ajpheart.00832.2003

Gouverneur M. Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx. AJP Heart Circ Physiol. 2005; 290(1): H458-2. DOI: 10.1152/ajpheart.00592.2005

Rehm M, Zahler S, Lötsch M, et al. Endothelial Glycocalyx as an Additional Barrier Determining Extravasation of 6% Hydroxyethyl Starch or 5% Albumin Solutions in the Coronary Vascular Bed. Anesthesiology. 2004; 100(5): 1211-23. DOI: 10.1097/00000542-200405000-00025

van Haaren PMA, VanBavel E, Vink H, et al. Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy. Am J Physiol Circ Physiol. 2003; 285(6): H2848-56. DOI: 10.1152/ajpheart.00117.2003

Ueda A. Effect of glycocalyx on shear-dependent albumin uptake in endothelial cells. AJP Heart Circ Physiol. 2004; 287(5): H2287-94. DOI: 10.1152/ajpheart.00808.2003

Van den Berg BM, Vink H, Spaan JAE. The endothelial glycocalyx protects against myocardial edema. Circ Res. 2003; 92(6): 592-4. DOI: 10.1161/01.RES.0000065917.53950.75

Chelazzi C, Villa G, Mancinelli P, et al. Glycocalyx and sepsis-induced alterations in vascular permeability. Crit Care. 2015; 19(1): 26. DOI: 10.1186/s13054-015-0741-z

Constantinescu AA, Vink H, Spaan JAE. Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface. Arterioscler Thromb Vasc Biol. 2003; 23(9): 1541-7. DOI: 10.1161/01.ATV.0000085630.24353.3D

Vink H, Duling BR. Capillary endothelial surface layer selectively reduces plasma solute distribution volume. Am J Physiol Heart Circ Physiol. 2000; 278(1): H285-9. DOI: 10.1007/s003390201284

Vink H, Constantinescu AA, Spaan JAE. Oxidized lipoproteins degrade the endothelial surface layer: Implications for platelet-endothelial cell adhesion. Circulation. 2000; 101(13): 1500-2. DOI: 10.1161/01.CIR.101.13.1500

Walpola PL, Gotlieb AI, Langille BL, et al. EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am J Physiol. 1991; 261(6 Pt2): H2016-23. DOI: 10.1152/ajpheart.1991.261.6.H2016

Hecker M, Mulsch A, Bassenge E, et al. Vasoconstriction and Increased Flow - 2 Principal Mechanisms of Shear Stress-dependent Endothelial Autacoid Release. Am J Physiol. 1993; 265(3 Pt 2): H828-33. DOI: 10.1152/ajpheart.1993.265.3.H828

Frangos JA, Eskin SG, McIntire LV, et al. Flow effects on prostacyclin production by cultured human endothelial cells. Science. 1985; 227(4693): 1477-9. DOI: 10.1126/science.3883488

Jacob M, Rehm M, Loetsch M, et al. The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation. J Vasc Res. 2007; 44(6): 435-43. DOI: 10.1159/000104871

Pries AR, Secomb TW, Gaehtgens P. The endothelial surface layer. Pflugers Arch Eur J Physiol. 2000; 440(5): 653-66. DOI: 10.1007/s004240000307

Broekhuizen LN, Mooij HL, Kastelein JJP, et al. Endothelial glycocalyx as a potential diagnostic and therapeutic target in cardiovascular disease. Curr Opin Lipidol. 2009; 20(1): 57-62. DOI: 10.1097/MOL.0b013e328321b587

Chappell D, Hofmann-Kiefer K, Jacob M, et al. TNF-α induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin. Basic Res Cardiol. 2009; 104(1): 78-89. DOI: 10.1007/s00395-008-0749-5

Becker BF, Chappell D, Bruegger D, et al. Therapeutic strategies targeting the endothelial glycocalyx: Acute deficits, but great potential. Cardiovasc Res. 2010; 87(2): 300-10. DOI: 10.1093/cvr/cvq137

Chappell D, Westphal M, Jacob M. The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness. Curr Opin Anaesthesiol. 2009; 22(2): 155-62. DOI: 10.1097/ACO.0b013e328328d1b6

van Teeffelen JW, Brands J, Stroes ES, et al. Endothelial Glycocalyx: Sweet Shield of Blood Vessels. Trends Cardiovasc Med. 2007; 17(3): 101-5. DOI: 10.1016/j.tcm.2007.02.002

Manon-Jensen T, Itoh Y, Couchman JR. Proteoglycans in health and disease: The multiple roles of syndecan shedding. FEBS J. 2010; 277(19):3876-89. DOI: 10.1111/j.1742-4658.2010.07798.x

Rubio-Gayosso I. Reactive oxygen species mediate modification of glycocalyx during ischemia-reperfusion injury. AJP Heart Circ Physiol. 2006; 290(6): H2247-56. DOI: 10.1152/ajpheart.00796.2005

Nelson A, Berkestedt I, Schmidtchen A, et al. Increased levels of glycosaminoglycans during septic shock: Relation to mortality and the antibacterial actions of plasma. Shock. 2008; 30(6): 623-7. DOI: 10.1097/SHK.0b013e3181777da3

Köhler M, Kaufmann I, Briegel J, et al. The endothelial glycocalyx degenerates with increasing sepsis severity. Crit Care. 2011; 15(Suppl 3): P22. DOI: 10.1186/cc10391

Steppan J, Hofer S, Funke B, et al. Sepsis and major abdominal surgery lead to flaking of the endothelial glycocalyx. J Surg Res. 2011; 165(1): 136-41. DOI: 10.1016/j.jss.2009.04.034

Sallisalmi M, Tenhunen J, Yang R, et al. Vascular adhesion protein-1 and syndecan-1 in septic shock. Acta Anaesthesiol Scand. 2012; 56(3): 316-22. DOI: 10.1111/j.1399-6576.2011.02578.x

Bruegger D. Atrial natriuretic peptide induces shedding of endothelial glycocalyx in the coronary vascular bed of guinea pig hearts. AJP Heart Circ Physiol. 2005; 289(5): H1993-9. DOI: 10.1152/ajpheart.00218.2005

Chappell D, Bruegger D, Potzel J, et al. Hypervolemia increases the release of atrial natriuretic peptide and shedding of the endothelial glycocalyx. Crit Care. 2014; 18: 538. DOI: 10.1186/s13054-014-0538-5

Powell M, Mathru M, Brandon A, et al. Assessment of endothelial glycocalyx disruption in term parturients receiving a fluid bolus before spinal anesthesia: A prospective observational study. Int J Obstet Anesth. 2014; 23(4): 330-4. DOI: 10.1016/j.ijoa.2014.06.001

Nieuwdorp M, Van Haeften TW, Gouverneur MCLG, et al. Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. Diabetes. 2006; 55(2): 480-6. DOI: 10.2337/diabetes.55.02.06.db05-1103


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