The role of endothelial glycocalyx in sepsis

I Nyoman Budi Hartawan , Made Wiryana

I Nyoman Budi Hartawan
Department of Anesthesiology, Pain Management, and Intensive Care Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia. Email:

Made Wiryana
Department of Anesthesiology, Pain Management, and Intensive Care Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia
Online First: April 28, 2019 | Cite this Article
Hartawan, I., Wiryana, M. 2019. The role of endothelial glycocalyx in sepsis. Bali Journal of Anesthesiology 3(1): 27-32. DOI:10.15562/bjoa.v3i1.114


The surface of endothelial cells is filled with various membrane-bound molecules that form the glycocalyx. The endothelial glycocalyx is a surface layer mainly consisted of glycosaminoglycans that include heparan sulfate, chondroitin sulfate, and hyaluronic acid and its core proteins. Previous studies suggest that endothelial surface glycocalyx shedding could play a role in endothelial dysfunction and inflammation. This article will review the endothelial glycocalyx and its role in sepsis. 



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