Salmonella Typhi – a Quiet Bacteria with a Loud Message: an ICU Case Report

Rossi Adu-Gyamfi , Fatima Hoosain, Sean Chetty

Rossi Adu-Gyamfi
1. Department of Surgery Tygerberg Academic Hospital/Stellenbosch University, Cape Town, South Africa 7505; 2. Department of Surgery 37 Military Hospital, Accra Ghana.. Email:

Fatima Hoosain
Department of Surgery Tygerberg Academic Hospital/Stellenbosch University, Cape Town, South Africa 7505;

Sean Chetty
Department of Anaesthesiology and Critical Care, Tygerberg Academic Hospital/Stellenbosch University, Cape Town, South Africa 7505
Online First: August 30, 2019 | Cite this Article
Adu-Gyamfi, R., Hoosain, F., Chetty, S. 2019. Salmonella Typhi – a Quiet Bacteria with a Loud Message: an ICU Case Report. Bali Journal of Anesthesiology 3(2). DOI:10.15562/bjoa.v3i0.161

Typhoid fever, caused by Salmonella enterica, serovar Typhi, is restricted to humans as its host and evades the human immune system with ease. This quality has been one of the many reasons why it is commonly found as an endemic bacterium in emerging economies. Also, due to a remarkably low yield from blood cultures (median of 1 CFU/mL of blood), Salmonella septicemia is uncommon. New evidence gathered together with clinical investigations have provided insight into the mechanisms that underlie the pathogenesis of typhoid, host restriction as well as antibiotic and vaccine susceptibility. However, very little has been done to curb the persistence of disease and emergence of resistant strains. We discuss a case of Salmonella Septic Shock in the Intensive Care Unit (ICU) that takes us through various aspects in diagnosis, the treatment potential and the problems surrounding prevention.


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